1-(1-Benzofuran-2-yl)-3-(4-chlorophenyl)prop-2-en-1-one

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1-(1-Benzofuran-2-yl)-3-(4-chlorophenyl)prop-2-en-1-one

In the title compound, C(17)H(11)ClO(2), the benzofuran ring system is almost planar (r.m.s. deviation = 0.011 Å) and forms a dihedral angle of 10.53 (6)° with the chloro-phenyl ring. No significant inter-molecular inter-actions are observed.

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3-(2-Methoxynaphthalen-1-yl)-2-benzofuran-1(3H)-one

The asymmetric unit of the title compound, C(19)H(14)O(3), contains two crystallographically independent mol-ecules in which the dihedral angles between the naphthalene and benzofuran ring systems are 76.49 (7) and 86.17 (7)°. In the crystal, mol-ecules are linked by inter-molecular C-H⋯O hydrogen-bonding inter-actions into chains running parallel to the a axis. In addition, the crystal packing...

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3-(4-Chlorophenyl)-1-(2-methyl-4-phenylquinolin-3-yl)prop-2-en-1-one

The crystal structure of the title compound, C(25)H(18)ClNO, shows that the mol-ecules are isolated and not involved in inter-molecular C-H⋯O or C-H⋯Cl inter-actions. However, the phenyl and quinoline rings are involved in π-π inter-actions [centroid-centroid distance = 3.8829 (9) Å].

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Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

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